Topical calcineurin inhibitors for atopic dermatitis: balancing clinical benefit and possible risks.
نویسندگان
چکیده
Purpose: This report has been written by AAQ at the request of NEASE. The purpose of the report is to provide an objective, independent view of the evidence surrounding the effectiveness and possible side effects of topical calcineurin inhibitors in response to the recent Food and Drug Administrations (FDA) concerns. The report is meant for patients with atopic dermatitis and their providers.
منابع مشابه
CSACI position statement: safety of topical calcineurin inhibitors in the management of atopic dermatitis in children and adults
Atopic dermatitis (AD) is a condition frequently encountered in medical practices across the country. Arming ourselves with appropriate and safe treatment modalities to provide relief for this chronic and relapsing inflammatory condition is of utmost importance to our patients and their families. Utilizing topical calcineurin inhibitors (TCIs) for the treatment of AD not responsive to high-pote...
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Atopic dermatitis (AD) is a chronic or chronically relapsing inflammatory skin condition that primarily affects children. Topical corticosteroids have been the mainstay of treatment since the late 1950s. While providing excellent short-term efficacy, topical corticosteroid usage is limited by potential adverse effects, including impairment of the function and viability of Langerhans cells/dendr...
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For more than five decades, topical corticosteroids and emollients have been the mainstay of therapy for atopic dermatitis. However, the potential for side-effects limits the clinical utility of corticosteroids in providing long-term disease control. With a unique mode of action that differs from that of corticosteroids, the steroid-free topical calcineurin inhibitors (TCIs), tacrolimus ointmen...
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Atopic dermatitis, one of the most common skin disorders in young children, has a prevalence of 10% to 20% in the first decade of life. It is a chronic illness that requires a multifaceted treatment strategy in the setting of limited therapeutic options. Balancing safety concerns with efficacious treatment is of particular importance in the pediatric population. Parents of patients with atopic ...
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Cutaneous lupus erythematosus (CLE) encompasses a variety of lesions that may be refractory to systemic or topical agents. Discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE) are the most common lesions in clinical practice. The topical calcineurin inhibitors, tacrolimus and pimecrolimus, have been used to treat resistant cutaneous lupus since 2002 and inhibit th...
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عنوان ژورنال:
- Archives of dermatology
دوره 142 5 شماره
صفحات -
تاریخ انتشار 2006